Which clinical history findings are characteristic of hypercalciuria?

Updated: Jun 02, 2021
  • Author: Stephen W Leslie, MD, FACS; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Note that hypercalciuria has no significant physical examination findings and is purely a laboratory diagnosis. Important aspects of the patient’s history may include the following:

  • Skeletal diseases (eg, osteoporosis, Paget disease) may produce hypercalciuria.

  • Immobilization for various reasons (eg, postoperative, orthopedic injury, burns, intensive care, spinal cord injury, bone marrow transplants) can cause rapid bone remodeling and, hence, elevated calcium excretion; fortunately, this has become less common owing to the use of early mobilization strategies and physical therapy

  • Nephrolithiasis is commonly associated with hypercalciuria

  • Malignancy is a common cause of hypercalcemia and hypercalciuria in hospitalized patients; it usually results from bone destruction, bone reabsorption, or humoral factors such as PTH-related protein.

  • Human immunodeficiency virus (HIV) infection or its treatment may be associated with a higher risk of hypercalciuria in children

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