What are the racial predilections of hypercalciuria?

Updated: Apr 23, 2019
  • Author: Stephen W Leslie, MD, FACS; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

White persons tend to have stones more often than do black individuals. Whether this is due to genetic differences or is secondary to dietary and socioeconomic factors is unclear, although the latter explanation is suggested by the increasing incidence of nephrolithiasis in the nonwhite population.

A study by Whalley and associates from Johannesburg, South Africa, found that black male stone formers had similar chemistry profiles to those of the white male stone formers, although the risk factors were generally less severe. [26] The investigators compared lithogenic risk factors in healthy black male volunteers, black males who were recurrent stone formers, and white male recurrent stone formers. The subjects were observed over a 10-year period and were assessed with a thorough history, dietary analysis, and serum and urinary chemistry evaluation. No significant family history of stone disease was present in the black population studied, which suggests that genetic factors may be of more importance in the etiology of stone formation among whites. [26]

Similar findings were reported by Maloney and associates, who found that all racial groups tested (white, black, Asian, Hispanic) demonstrated remarkable similarity in the incidence of underlying metabolic abnormalities. [27]

A study by Rodgers and Lewandowski found that a low-calcium diet caused a statistically significant increase in urinary oxalate in black subjects but not in white subjects. [28] The results of a high-oxalate diet also differed between the black and white groups. [28]


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