Which clinical history findings are characteristic of Haemophilus influenzae infections?

Updated: Jul 02, 2019
  • Author: Joseph Adrian L Buensalido, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Answer

Pulmonary disease, HIV infection (and other immunodeficiency states), alcoholism, pregnancy, and malignancy may predominate in adults with invasive Hib disease.

Patients with primary ciliary dyskinesia, an inherited condition with motile cilia dysfunction, have been shown to grow H influenzae from sputum and nasal lavage. More recently, these same patients appear to be susceptible to the development of NTHi biofilm, as seen in both culture and confocal and scanning microscopy. [31, 32]

NTHi is considered a common commensal in the nasopharynx, but when it reaches the lower respiratory tree in patients with COPD, it is associated with significant inflammation that generally leads to morbidity due to worsening symptoms and more frequent COPD exacerbations. [33, 34]


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