Which lab tests are performed in the workup of Haemophilus influenzae infections?

Updated: Jun 11, 2021
  • Author: Joseph Adrian L Buensalido, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Answer

Laboratory testing includes the following:

  • Gram staining of body fluids from various sites of infection

  • Bacterial culture (blood, other body fluids): The most confirmatory method of establishing the diagnosis; slide agglutination with type-specific antisera is used for serotyping H influenzae

  • Immunologic studies: Detection of the polyribosyl ribitol phosphate (PRP) polysaccharide capsule via countercurrent immunoelectrophoresis, latex particle agglutination, co-agglutination, and enzyme-linked immunosorbent assay; important adjuncts to culturing for rapid diagnosis

  • Cerebrospinal fluid (CSF) studies (eg, Gram stain, culture, glucose/protein levels)

  • Blood cell counts: Assessment for anemia, leukocytosis, thrombocytosis, and/or thrombocytopenia

  • Acute phase reactants: Characteristic elevated erythrocyte sedimentation rates (ESRs) and C-reactive protein (CRP) levels in patients with septic arthritis


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