What are the signs and symptoms of Haemophilus influenzae infections?

Updated: Jun 11, 2021
  • Author: Joseph Adrian L Buensalido, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Signs and symptoms are as follows:

  • Hib meningitis: Most serious manifestation of Hib infection; antecedent upper respiratory tract infections are common; Hib meningitis manifestations indistinguishable from other bacterial meningitis causes
  • Cellulitis: Most commonly involves the buccal and periorbital regions; usually associated with fever
  • Epiglottitis: Fever, sore throat, dysphagia, drooling, and difficulty breathing
  • Hib pneumonia: Clinically indistinguishable from other bacterial pneumonias—but usually with insidious onset and a history of fever, cough, and purulent sputum production
  • Hib pericarditis: Fever, respiratory distress, and tachycardia
  • Septic arthritis: Joint pain, swelling, and decreased mobility
  • Occult bacteremia: Fever, anorexia, and lethargy
  • Underlying medical conditions (especially with invasive Hib disease): Pulmonary disease, immunodeficiency states (eg, HIV infection), alcoholism, pregnancy, and malignancy
  • Neonatal infections: May have nonspecific manifestations; may include signs/symptoms of bacteremia, sepsis, meningitis, pneumonia, respiratory distress, scalp abscess, conjunctivitis, and vesicular eruption
  • NTHi infections: Commonly causes various mucosal infections, including otitis media and conjunctivitis

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