What are the WHO treatment guidelines for genital and anorectal gonorrhea?

Updated: Sep 07, 2018
  • Author: Brian Wong, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Answer

Guidelines on the treatment of Neisseria gonorrhoeae by the World Health Organization (WHO) are summarized below. [80]

Genital and anorectal gonococcal infections

Treatment recommendations by the WHO for genital and anorectal gonococcal infections are as follows:

  • Ceftriaxone 250 mg IM as a single dose plus azithromycin 1 g PO as a single dose
  • Cefixime 400 mg PO as a single dose plus azithromycin 1 g PO as a single dose
  • Single-drug therapy (one of the following, based on recent local resistance data confirming susceptibility to the antimicrobial): Ceftriaxone 250 mg IM as a single dose; cefixime 400 mg PO as a single dose; or spectinomycin 2 g IM as a single dose

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