What progress has been made in the development of a vaccine against gonococcal?

Updated: Jun 15, 2021
  • Author: Shahab Qureshi, MD, FACP; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Answer

Several factors, including the lack of an animal model and the diverse antigenic variability of gonorrhea, have made creation of a gonococcal vaccine difficult. Based on rabbit studies, a pilin target was the most likely vaccine candidate. Early tests in military recruits and in volunteers met with some success, but protection was strain-limited, once again because of high antigenic variation of pili. A vaccine toward porins was also evaluated, but induced anti-porin antibodies were not bactericidal. [28]

PRO-2000, an antimicrobial gel for the potential prevention of HIV infection, is in phase 3 trials for the prevention of sexually transmitted infections, including HIV, herpes, chlamydia, and gonorrhea, in Africa. [73]


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