What is the prevalence of antibiotic-resistant gonorrhea in the US?

Updated: Jun 15, 2021
  • Author: Shahab Qureshi, MD, FACP; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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The incidence of antibiotic-resistant strains of N gonorrhoeae has been rising since the late 1940s. Of greatest concern is the rise in the percentage of cases due to N gonorrhoeae with higher minimum inhibitory concentrations (MICs) to ceftriaxone, the current treatment of choice. As per the Gonococcal Isolate Surveillance Project (GISP) only 0.1% of isolates displayed elevated ceftriaxone minimum inhibitory concentrations (MICs) in 2019. [24, 6]

In May 2016, the first cluster of highly resistant gonorrhea infections in the United States was identified in Hawaii. Most of the isolates showed decreased susceptibility to ceftriaxone, and all cases had very high-level resistance to azithromycin. [25]

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