Which symptoms suggest a malignant cause of fever of unknown origin (FUO)?

Updated: Mar 01, 2018
  • Author: Sandra G Gompf, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Historical clues to malignant causes of FUO are as follows:

  • Pel-Ebstein fever in Hodgkin disease (week-long high fevers with week-long remissions)
  • Lymphadenopathy, painless: Lymphoma, leukemia
  • Weight loss with anorexia
  • Itching after a hot bath: Lymphoma
  • Erythema nodosum, painful nodules on shins: Lymphoma

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