What are noninfectious inflammatory causes of fever of unknown origin (FUO)?

Updated: Mar 01, 2018
  • Author: Sandra G Gompf, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

The causes of FUO are often common conditions presenting atypically. Listed below are the most common, less common, and least common in their respective categories, but by no means the only causes.

Noninfectious Inflammatory Causes of FUO (Connective Tissue Diseases, Vasculitides, and Granulomatous Disorders)

The most common noninfectious inflammatory causes of FUO include the following:

  • Giant cell (temporal) arteritis
  • Adult Still disease (juvenile rheumatoid arthritis)

Less-common noninfectious inflammatory causes of FUO include the following:

  • Systemic lupus erythematosus (SLE)
  • Periarteritis nodosa/microscopic polyangiitis (PAN/MPA)
  • Rheumatoid arthritis (RA)

The least common noninfectious inflammatory causes of FUO include the following:

  • Antiphospholipid syndrome (APS)
  • Gout
  • Pseudogout
  • Behçet disease
  • Sarcoidosis
  • Felty syndrome
  • Takayasu arteritis
  • Kikuchi disease
  • Periodic fever adenitis pharyngitis aphthous ulcer (PFAPA) syndrome

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