How are the conditions of the differential diagnosis of fever of unknown origin (FUO) categorized?

Updated: Mar 01, 2018
  • Author: Sandra G Gompf, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Causes of FUO may differ geographically based on regional exposures, economic development, and available diagnostic tools. For example, in developing countries, infection may predominate, while noninfectious inflammatory and malignant conditions are more common in developed countries.  The focus of this article is FUO in developed countries; however, travel-associated causes that may present from developing countries should not be missed.

The list of etiologic possibilities is extensive, and it is helpful to break the differential diagnoses into broader categories, such as infection, noninfectious inflammatory conditions, malignancies, and miscellaneous. In recent years, noninfectious inflammatory disorders predominate, with infection now second.

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