Which bismuth-based therapy for the eradication of Helicobacter pylori infection may be effective for antibiotic-resistant pathogens?

Updated: Dec 09, 2020
  • Author: Joseph Adrian L Buensalido, MD; more...
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Answer

Answer

Chinese researchers reported that the following regimen provides effective first-line treatment in a population with high antibiotic resistance [31] :

  • Rabeprazole 10 mg BID  plus
  • Bismuth potassium citrate 220 mg BID  plus
  • Amoxicillin 1000 mg BID  plus
  • Clarithromycin 500 mg BID

Duration is 10 days. Rabeprazole and bismuth were given 30 min before the morning and evening meals. Antibiotics were given 30 min after the morning and evening meals. [31]

Researchers in Turkey, however, reported that a 14-day regimen of lansoprazole 30 mg BID, amoxicillin 1000 mg BID, clarithromycin 500 mg BID, bismuth subsalicylate 600 mg BID was not significantly superior to a 7-day regimen (81.4% vs. 80%). [32]


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