What is reverse hybrid nonbismuth quadruple therapy for the eradication of Helicobacter pylori infection?

Updated: Dec 09, 2020
  • Author: Joseph Adrian L Buensalido, MD; more...
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Reverse hybrid therapy is a combination of sequential and concomitant therapy, using the same drugs as hybrid therapy, but in reverse sequence, [26]  as follows:

  1. PPI plus amoxicillin plus 2 other antibiotics (usually, clarithromycin and metronidazole) for 7 days then
  2. PPI plus amoxicillin for 3–7 days

The eradication rate achieved with 12 days of reverse hybrid therapy is similar to that with 12 days of hybrid therapy (95.7% vs. 95.1%, respectively).

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