What is hybrid nonbismuth quadruple therapy for the eradication of Helicobacter pylori infection?

Updated: Dec 09, 2020
  • Author: Joseph Adrian L Buensalido, MD; more...
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Hybrid therapy is a combination of sequential and concomitant therapy, [3, 25, 26] as follows:

  1. PPI plus amoxicillin for 3 - 7 days (the latter recommended as another suggested first-line option in the 2017 American College of Gastroenterology Guideline [2] ), then

  2. PPI plus amoxicillin plus 2 other antibiotics (usually, clarithromycin and metronidazole) for 7 days

There is evidence that the eradication rates with 10-day, 12-day and 14-day regimens are comparable at 95.0%, 95.1%, and 93.4%, respectively. This suggests that the optimal duration of hybrid therapy is 12 days, since high rates of eradication are still achieved.

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