What is concomitant nonbismuth quadruple therapy for the eradication of Helicobacter pylori infection?

Updated: Dec 09, 2020
  • Author: Joseph Adrian L Buensalido, MD; more...
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Answer

Answer

Concomitant therapy (an alternative first-line option [2] ) consists of the following (using dosages similar to those in triple therapy; or all drugs BID in one study):

  • PPI plus

  • Amoxicillin plus

  • Clarithromycin (1 g modified-release tablet QD in one study) plus

  • Metronidazole (500 mg TID in one study)

Duration of concomitant therapy is 10-14 days. [2, 19, 20]

Concomitant therapy is better for clarithromycin-resistant strains, [19, 4] and 14 days of concomitant therapy is superior to 14-day triple therapy, with cure rates of ≥90%. [21, 22, 23, 24]


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