What are the CDC guidelines for initial combination regimens for the treatment of HIV infection?

Updated: Jan 15, 2019
  • Author: Jason F Okulicz, MD, FACP, FIDSA; more...
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An initial antiretroviral regimen generally consists of two nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) in combination with a third active drug from one of the following classes: nonnucleoside reverse transcriptase inhibitor (NNRTI), protease inhibitor (PI; boosted with ritonavir or cobicistat), or integrase strand transfer inhibitor (INSTI).

Selection of a regimen should be individualized based on virologic efficacy, potential adverse effects, pill burden, dosing frequency, drug-drug interaction potential, the patient's resistance test results, comorbid conditions, and cost.

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