What is occupational HIV postexposure prophylaxis (PEP)?

Updated: Nov 14, 2019
  • Author: Jason F Okulicz, MD, FACP, FIDSA; more...
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Postexposure prophylaxis (PEP) is recommended for health-care personnel who have occupational exposure to blood or other body fluids that may contain human immunodeficiency virus (HIV). [1, 2] The HIV status of the exposure source patient should be determined, if possible, to guide the need for HIV PEP. PEP medication regimens should be started as soon as possible after occupational exposure to HIV, and they should be continued for a 4-week duration. PEP medication regimens should contain 3 (or more) antiretroviral drugs for all occupational exposures to HIV.

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