What is the role of prokinetic agents in the treatment of constipation?

Updated: May 18, 2020
  • Author: Abimbola Farinde, PharmD, PhD; more...
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Prokinetic agents promote intestinal motility and are used for severe constipation-predominant symptoms associated with irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC). [7] Prokinetic agents include the following:

  • Linaclotide - Guanylate cyclase C (GC-C) agonist that activates GC-C located on the luminal surface of intestinal epithelial cells; stimulation leads to increased cyclic guanosine monophosphate (cGMP), anion secretion, fluid secretion, and intestinal transit

  • Lubiprostone - Locally acting chloride channel activator that increases intestinal fluid secretion and intestinal motility; acts locally at apical portion of the intestine

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