How is Stevens-Johnson syndrome differentiated from enteroviral disease?

Updated: Mar 17, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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The cutaneous manifestations of human enterovirus infections include widespread blistering mucocutaneous reactions without any suspected drug causality. [61] A new variant of coxsackievirus A6 has been identified in the Republic of China as the causative agent for severe mucocutaneous blistering reactions similar to what one may see with severe cutaneous adverse reactions, characterized as resembling the Stevens-Johnson syndrome complete with erythema multiform–like plaques. In addition, the histologic patterns was that of erythema multiforme major/Stevens-Johnson syndrome.

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