What is the virology of enteroviruses?

Updated: Mar 01, 2018
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
  • Print
Answer

The enteroviruses are icosahedral nonenveloped viruses that are approximately 30 nm in diameter.

They have a capsid composed of 60 subunits each formed from 4 proteins (VP1 to VP4).

They are stable at a pH from 3-10, distinguishing them from other picornaviruses (including rhinoviruses), which are unstable below pH 6.

A linear, single-strand RNA genome of about 7.5 kb is enclosed by the capsid; the translation product is a single polyprotein that is cleaved after translation by viral-coded proteases into the structural proteins (VP1 to VP4), RNA polymerase, proteases, and other nonstructural proteins. [13]

Enteroviruses resist lipid solvents, ether, chloroform, and alcohol. They are inactivated at temperatures above 50°C but remain infectious at refrigerator temperature.

Molar MgCl2 reduces thermolability at higher temperatures.

The viruses are inactivated by ionizing radiation, formaldehyde, and phenol.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!