What antibiotic restrictions should be followed when treating enterococcal infections?

Updated: Jun 10, 2021
  • Author: Susan L Fraser, MD; Chief Editor: John L Brusch, MD, FACP  more...
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Restriction of other antibiotics includes the following:

  • In a prospective study of VRE-colonized patients, the authors have demonstrated that antianaerobic antibiotics promote persistent high-density stool colonization. Limiting the use of these agents in colonized patients may also help to limit the spread of VRE.

  • In a prospective cohort study, an enhanced infection-control strategy, including a program for reducing total antimicrobial use, resulted in reduced VRE transmission in an oncology unit compared with standard VRE infection-control practices.

  • Compared with the standard infection-control period, the use of vancomycin, imipenem-cilastatin, ceftazidime, ciprofloxacin, aztreonam, and gentamicin during the enhanced infection control period was significantly reduced.

  • The incidence of both VRE bloodstream infections and rectal colonization decreased significantly during the enhanced infection-control period.

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