What is the role of tigecycline in the treatment of Enterobacter infections?

Updated: Dec 05, 2018
  • Author: Susan L Fraser, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Newer options include tigecycline. Although not indicated specifically for Enterobacter pneumonia or bloodstream infections, tigecycline has excellent in vitro activity against these gram-negative bacilli. [22, 23, 24] In one laboratory study of multidrug-resistant gram-negative bacilli, tigecycline maintained a low MIC against all of the organisms. [25] Older options might include intravenous administration of polymyxin B or colistin, drugs that are rarely used, even in large medical centers, and for which standard susceptibility criteria are not available. A study of 89 carbapenem nonsusceptible Enterobacteriaceae isolates from China showed that polymyxin B was much more active than tigecycline. [26]


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