What is the traditional approach to treatment of S aureus bacteremia in infective endocarditis (IE)?

Updated: Jan 03, 2019
  • Author: John L Brusch, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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In the past, management of S aureus bacteremia in the presence of an intravascular catheter required promptly removing the catheter, initiating appropriate antibiotic therapy, monitoring of blood culture results in 24-48 hours, and performing transthoracic echocardiography (TTE).

If follow-up blood culture and TTE findings were negative and no evidence of metastatic infection was found, two weeks of antistaphylococcal therapy was believed to be appropriate.

If the follow-up blood culture findings are positive, TEE should be performed. If TEE demonstrates findings of valvular infection, the patient is to be treated for 4-6 weeks with antistaphylococcal antibiotics.

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