What is the treatment for native valve endocarditis (NVE) caused by methicillin-sensitive S aureus (MSSA)?

Updated: Jan 03, 2019
  • Author: John L Brusch, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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NVE caused by methicillin-sensitive S aureus (MSSA) should be treated as follows:

  • Administer nafcillin or oxacillin at 2 g IV every 4 hours for 4-6 weeks
  • Administer cefazolin at 2 g IV every 8 hours for 4-6 weeks
  • For patients who are allergic to penicillin, administer vancomycin at 30 mg/kg (usually, do not to exceed 2 g/24 h unless serum levels are monitored) for 4-6 weeks; a peak vancomycin level of 30-45 mcg/mL should be attained 1 hour after completion of the intravenous infusion.

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