What are the rejection criteria for the diagnosis of infective endocarditis (IE)?

Updated: Jan 03, 2019
  • Author: John L Brusch, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

A diagnosis of possible IE is made when findings consistent with IE fall short of the criteria for definite IE but do not meet the criteria for rejection.

Rejection criteria for the diagnosis of IE are as follows:

  • The presence of a firm alternative diagnosis of the manifestations of endocarditis

  • Resolution of manifestations of endocarditis after 4 or fewer days of antimicrobial therapy

  • No pathologic evidence of IE at surgery or autopsy after 4 or fewer days of antimicrobial therapy

These criteria may, at times, overdiagnose IE and may not be as applicable in patients with subacute disease.


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