What are the major blood culture criteria for infective endocarditis (IE)?

Updated: Jan 03, 2019
  • Author: John L Brusch, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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Major blood culture criteria include the following:

  • Two blood cultures positive for organisms typically found in patients with IE (ie, S viridans, Streptococcus bovis, a HACEK group organism, community-acquired S aureus, or enterococci in the absence of a primary focus)

  • Blood cultures persistently positive for one of the above organisms from cultures drawn more than 12 hours apart

  • Three or more separate blood cultures drawn at least 1 hour apart

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