What are the characteristics and complications of nosocomial infective endocarditis (NIE)?

Updated: Jan 03, 2019
  • Author: John L Brusch, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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NIE commonly manifests with elements of a sepsis syndrome (ie, hypotension, metabolic acidosis fever, leukocytosis, and multiple organ failure). The source of bacteremia may develop from an infection in another organ (eg, pneumonia, pyelonephritis) or from a central venous catheter. Most often, these patients are in the intensive care unit.

The aging of the population is associated with an increased incidence of staphylococcal healthcare-associated endocarditis, in addition to an increased mortality rate associated with the disease. [41]

Approximately 45% of cases of NIE/HCIE occur in patients with prosthetic valves.

IE associated with dialysis catheters has a fairly high rate of MRSA involvement. Eighty percent of cases involve the mitral valve. [42]

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