What are the cure rates for native valve endocarditis (NVE) and prosthetic valve endocarditis (PVE)?

Updated: Jan 03, 2019
  • Author: John L Brusch, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Cure rates for appropriately managed (including both medical and surgical therapies) NVE are as follows:

  • For S viridans and S bovis infection, the rate is 98%.

  • For enterococci and S aureus infection in individuals who abuse intravenous drugs, the rate is 90%.

  • For community-acquired S aureus infection in individuals who do not abuse intravenous drugs, the rate is 60-70%.

  • For infection with aerobic gram-negative organisms, the rate is 40-60%.

  • For infection with fungal organisms, the rate is lower than 50%.

For PVE, the cure rates are as follows:

  • Rates are 10-15% lower for each of the above categories, for both early and late PVE.

  • Surgery is required far more frequently.

  • Approximately 60% of early CoNS PVE cases and 70% of late CoNS PVE cases are curable.


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