What are the major blood culture diagnostic criteria for infective endocarditis (IE)?

Updated: Jan 03, 2019
  • Author: John L Brusch, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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Major blood culture criteria for IE include the following:

  • Two blood cultures positive for organisms typically found in patients with IE

  • Blood cultures persistently positive for one of these organisms, from cultures drawn more than 12 hours apart

  • Three or more separate blood cultures drawn at least 1 hour apart

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