What is the role of vaccines in the prevention of coccidioidomycosis?

Updated: Aug 27, 2019
  • Author: Duane R Hospenthal, MD, PhD, FACP, FIDSA, FASTMH; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

No vaccines to prevent coccidioidomycosis currently are used in humans. [93] A killed spherule-derived vaccine was found to be efficacious in animals but not protective in humans.

Multiple Coccidioides species cell-surface antigens have been investigated for their ability to stimulate protective T-cell-mediated immune responses. [82] Currently, recombinant DNA techniques to develop vaccines using the proline-rich [94] and other antigens from the Coccidioides spherule appear promising.


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