What is the role of interferon-gamma in the treatment of coccidioidomycosis?

Updated: Aug 27, 2019
  • Author: Duane R Hospenthal, MD, PhD, FACP, FIDSA, FASTMH; Chief Editor: Michael Stuart Bronze, MD  more...
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Suggestions have been made for the use of interferon-gamma in the treatment of fungal infections, given their association with cell-mediated immunity, although coccidioidomycosis was not specifically mentioned among them. [76]  The description of a case of disseminated severe coccidioidomycosis in a patient with autosomal dominant interferon-gamma receptor 1 deficiency certainly suggests more research in the area. [83] Clinical trials are necessary to evaluate promising in vitro findings against Coccidioides and other dimorphic fungal infections.

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