What is the role of combination therapies in the treatment of coccidioidomycosis?

Updated: Aug 27, 2019
  • Author: Duane R Hospenthal, MD, PhD, FACP, FIDSA, FASTMH; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

In very severe cases, combination therapy with amphotericin and an azole have been postulated, although no trials have been conducted. Caspofungin in combination with fluconazole has been cited as beneficial in a case report of a 31-year-old Korean man with coccidioidal pneumonia. [72] In a case report of a 23-year-old black male with HIV and coccidioidal meningitis, combination therapy of amphotericin B and posaconazole led to clinical improvement. [73]


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