Which methods of immunoglobulin M (IgM) detection are used in the workup of coccidioidomycosis?

Updated: Aug 27, 2019
  • Author: Duane R Hospenthal, MD, PhD, FACP, FIDSA, FASTMH; Chief Editor: Michael Stuart Bronze, MD  more...
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Methods of IgM detection are as follows:

  • Tube precipitin - Older test, not currently in use

  • Immunodiffusion tube precipitin - Better specificity; requires more time to perform than latex agglutination or enzyme immunoassay

  • Latex agglutination - Rapid and highly sensitive but lacks specificity; higher false-positive rate and positive results require confirmation with another test (ie, immunodiffusion tube precipitin)

  • Enzyme immunoassay (EIA) - Highly sensitive but lacks specificity; positive result requires confirmation with immunodiffusion tube precipitin

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