How is coccidioidomycosis diagnosed?

Updated: Aug 27, 2019
  • Author: Duane R Hospenthal, MD, PhD, FACP, FIDSA, FASTMH; Chief Editor: Michael Stuart Bronze, MD  more...
  • Print
Answer

Observation of Coccidioides in a clinical specimen establishes the diagnosis. Specimens may include any of the following:

  • Sputum

  • Bronchoalveolar lavage fluid [47]

  • Blood

  • Urine

  • Bone marrow

  • Lymph nodes

  • Skin lesions

  • Cerebrospinal fluid

  • Biopsy specimens

Coccidioides urinary antigenemia has been found positive in more than 70% of immunocompromised patients with HIV/AIDS or solid organ transplant; no reports on its sensitivity in less compromised or immunocompetent patients are available. [48] One study has suggested an association between low serum mannose-binding lectin (MBL) levels and symptomatic coccidioidomycosis. [49]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!