What are the limitations of vaccine in the prevention of dengue?

Updated: May 03, 2019
  • Author: Darvin Scott Smith, MD, MSc, DTM&H; Chief Editor: Michael Stuart Bronze, MD  more...
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Immunity to a single dengue strain is the major risk factor for severe dengue; as such, a vaccine must provide high levels of immunity to all 4 dengue strains to be clinically useful. [93] Seroconversion alone does not predict protection. Several other immunogenic tetravalent vaccine candidates have been developed, and two are in phase 3 clinical trials. [94, 95, 96, 97, 98]

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