What are the limitations of vaccine in the prevention of dengue?

Updated: May 03, 2019
  • Author: Darvin Scott Smith, MD, MSc, DTM&H; Chief Editor: Michael Stuart Bronze, MD  more...
  • Print
Answer

Immunity to a single dengue strain is the major risk factor for severe dengue; as such, a vaccine must provide high levels of immunity to all 4 dengue strains to be clinically useful. [93] Seroconversion alone does not predict protection. Several other immunogenic tetravalent vaccine candidates have been developed, and two are in phase 3 clinical trials. [94, 95, 96, 97, 98]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!