What are the causes of thrombocytopenia in dengue?

Updated: May 03, 2019
  • Author: Darvin Scott Smith, MD, MSc, DTM&H; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Several recent studies have investigated the causes of thrombocytopenia in dengue. Laboratory and human studies have suggested a direct correlation between activation and depletion of platelets, with a sharp drop occurring on day 4 of fever. A high number of dengue virus genome copies have been found in these activated platelets. Increased binding of complement C3 and IgG have also been found on the surface of these platelets. In addition to platelet activation, dengue infection has been found to activate the intrinsic pathway of apoptosis, with increased surface phosphatidylserine exposure, mitochondrial depletion, and activation of caspase 3 and 9. [37]


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