What is the pathophysiology for dengue?

Updated: May 03, 2019
  • Author: Darvin Scott Smith, MD, MSc, DTM&H; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Dengue fever is a mosquito-borne viral disease caused by 1 of 4 closely related but antigenically distinct serotypes of dengue virus, serotypes DENV-1 through DEN-4. [17] Infection with one dengue serotype confers lifelong homotypic immunity and a brief period of partial heterotypic immunity (2 years), but each individual can eventually be infected by all 4 serotypes. Several serotypes can be in circulation during an epidemic.


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