Which medications in the drug class Antidiarrheal Agents are used in the treatment of Cryptosporidiosis?

Updated: Nov 11, 2019
  • Author: Melinda B Tanabe, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Antidiarrheal Agents

These agents are used to decrease the frequency of diarrheal stools and possibly the duration of episodes.

Loperamide hydrochloride (Imodium, Diamode)

This agent has an antimotility effect on the GI tract via cholinergic and opiate receptors. It is the first choice as an antidiarrheal agent. Loperamide hydrochloride has a more potent effect than diphenoxylate hydrochloride or codeine. It acts on intestinal muscles to inhibit peristalsis and slow intestinal motility. The drug prolongs the movement of electrolytes and fluid through bowel, increases viscosity, and decreases the loss of fluids and electrolytes.

Diphenoxylate and atropine (Lomotil)

The drug combination consists of diphenoxylate, which is an opiate constipating meperidine congener, and atropine, which an anticholinergic drug that inhibits excessive GI propulsion and motility.

Paregoric

The opiate anhydrous morphine, which is contained in paregoric, can decrease motility more than loperamide or the combination of diphenoxylate and atropine can.

Bismuth subsalicylate (Pepto-Bismol, Bismatrol, Kaopectate)

This agent exerts antisecretory and antibacterial effects to control diarrhea.

Attapulgite

Attapulgite is an adsorbent and protectant that controls diarrhea.


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