What is the role of primary and secondary immunodeficiency screening in the workup of cryptosporidiosis?

Updated: Nov 11, 2019
  • Author: Melinda B Tanabe, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Primary immunodeficiencies

Children with chronic diarrhea from cryptosporidiosis should be screened for primary immunodeficiencies associated with depressed cellular immune function. The most commonly identified immunodeficiency is hyper-IgM syndrome, which can be identified by antibody screening. T-cell deficiencies can be identified by examining lymphocyte numbers and subsets. [49]

Secondary immunodeficiencies

In organ transplant recipients who are receiving immunosuppressive medications, immunosuppression should be minimized and levels of tacrolimus and cyclosporine monitored to avoid toxicity. [38]


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