Which medications in the drug class Antihistamines, 1st Generation are used in the treatment of Dizziness, Vertigo, and Imbalance?

Updated: Mar 13, 2017
  • Author: Hesham M Samy, MD, PhD; Chief Editor: Robert A Egan, MD  more...
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Answer

Antihistamines, 1st Generation

Antihistamines prevent the histamine response in sensory nerve endings and blood vessels and are effective in treating vertigo.

Meclizine (Antivert, Medi-Meclizine, Trav-L-Tabs)

Meclizine decreases the excitability of the inner-ear labyrinth and blocks conduction in inner-ear vestibular-cerebellar pathways. Its effects are associated with therapeutic effects in relief of nausea and vomiting. It is most effective if used as needed for 2-3 days with episodes of true vertigo.

Dimenhydrinate (Dramamine, Driminate, Triptone)

Dimenhydrinate is a 1:1 salt of 8-chlorotheophylline and diphenhydramine that is believed to be particularly useful in the treatment of vertigo. It diminishes vestibular stimulation and depresses labyrinthine function by means of its central anticholinergic activity.


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