Which medications in the drug class Phenothiazine Derivatives are used in the treatment of Dizziness, Vertigo, and Imbalance?

Updated: Mar 13, 2017
  • Author: Hesham M Samy, MD, PhD; Chief Editor: Robert A Egan, MD  more...
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Phenothiazine Derivatives

Phenothiazines are effective in treating emesis, possibly because of their effects in the dopaminergic mesolimbic system.

Promethazine (Phenergan, Phenadoz, Promethegan)

Promethazine is an antidopaminergic drug that is effective in the treatment of emesis. It blocks postsynaptic mesolimbic dopaminergic receptors in the brain and reduces stimuli to the brainstem reticular system. Glycopyrrolate is safer and has fewer adverse effects. Promethazine is well tolerated by elderly patients and does not have the potential for causing extrapyramidal syndrome.

Prochlorperazine (Compro)

Prochlorperazine is an antidopaminergic drug that blocks postsynaptic mesolimbic dopamine receptors. It has anticholinergic activity and can depress the reticular activating system (this effect may be responsible for relief of nausea and vomiting).

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