What are the treatment options for chlamydial genitourinary infections (chlamydia)?

Updated: Sep 25, 2018
  • Author: Shahab Qureshi, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Treatment of genitourinary chlamydial infection is clearly indicated when the infection is diagnosed or suspected. Chlamydiae are susceptible to antibiotics that interfere with DNA and protein synthesis, including tetracyclines, macrolides, and quinolones. [47] CDC recommends azithromycin and doxycycline as first-line drugs for the treatment of chlamydial infection. [33, 40] Medical treatment with these agents is 95% effective. Alternative agents include erythromycin, levofloxacin, and ofloxacin. [33] Rifalazil, a rifamycin that is highly active against C trachomatis and has a long half-life, has shown promise as a single-dose treatment for chlamydial nongonococcal urethritis and is currently being evaluated in women with uncomplicated genital infection. [48]


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