What are the CDC recommendations for the use of nucleic acid amplification tests (NAATs) in the diagnosis of chlamydial genitourinary infections (chlamydia)?

Updated: Sep 25, 2018
  • Author: Shahab Qureshi, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

NAATs that are cleared by the FDA are recommended for detection of genital tract infections caused by C trachomatis and N gonorrhoeae in men and women with or without symptoms. [44] Older nonculture tests and non-NAATs have inferior sensitivity and specificity characteristics and are no longer recommended.

NAATs have not been cleared by FDA for the detection of rectal and oropharyngeal infections caused by C trachomatis. The Centers for Disease Control and Prevention (CDC) recommends NAATs to test for these extragenital infections based on increased sensitivity, ease of specimen transport, and processing. Routine repeat testing of NAAT-positive genital tract specimens is not recommended because the practice does not improve the positive predictive value of the test. C trachomatis and N gonorrhoeae culture capacity might still be needed in instances of child sexual assault in boys and extragenital infections in girls. [44]


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