How is congenial transmission of Chagas disease (American trypanosomiasis) prevented?

Updated: Apr 26, 2019
  • Author: Louis V Kirchhoff, MD, MPH; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Little information has been published that sheds light on the question of whether the rate of congenital transmission can be reduced by prophylactically treating women of child‑bearing age with either nifurtimox or benznidazole before they become pregnant. In the one investigation relevant to this question, [160] only a small number of women in the study group received treatment as adults. No data regarding the suppression of parasitemias or parasitological cure were included in the report. None of the infants born to the women in the study had congenital Chagas disease, suggesting that treatment of women with chronic T cruzi infection prior to pregnancy may be effective in reducing congenital transmission. This question needs to be addressed in a larger study.

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