What are the CDC guidelines for the medical treatment of Chagas disease (American trypanosomiasis)?

Updated: Apr 26, 2019
  • Author: Louis V Kirchhoff, MD, MPH; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Answer

Current CDC guidance states that treatment is strongly recommended for adults aged 50 years or younger with chronic infection who do not already have advanced Chagas cardiomyopathy. [146] The current recommendations of the Ministries of Health in Brazil [158] and Argentina [159] are consistent with those from the 2006 CDC meeting as published. [142] However, since these recommendations are not evidence‑based, the results from the BENEFIT trial, and the appearance of bothersome side effects in a substantial proportion of treated patients, the author of this article does not support benznidazole or nifurtimox treatment in adults with chronic T cruzi infection, regardless of their clinical status. It merits mention that the CDC guidance and the recommendations of the Ministries of Health in Brazil and Argentina have not been updated since the results of the BENEFIT trial have been published.


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