Which antibiotics are recommended in the treatment of adult Staphylococcus aureus (MSSA) infections?

Updated: Jun 14, 2019
  • Author: Thomas E Herchline, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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The following are first-line treatments in managing adult S aureus (MSSA) infections [2] :

  • Nafcillin (for patients with severe penicillin hypersensitivity: vancomycin, linezolid, quinupristin-dalfopristin, or daptomycin; add an appropriate agent in the presence of [or if there is a suspicion of] staphylococcal infection) or oxacillin 1-2 IV q4h

  • Cefazolin 1 g IV q8h

  • Clindamycin 600-900 mg/kg IV q8h (may have cross-resistance and emergence resistance in erythromycin-resistant strains; induces resistance in MRSA)

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