Which antibiotics are recommended to treat MRSA skin and soft-tissue infections (SSTIs) in children?

Updated: Jun 14, 2019
  • Author: Thomas E Herchline, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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The IDSA indicates that the following pediatric (except neonates) antibiotic regimens may be used to treat MRSA SSTIs [2] :

  • Vancomycin 40 mg/kg/day IV, in 4 divided doses (IV agent of choice for MRSA; penicillin-allergic patients)

  • Linezolid 10 mg/kg IV q12h or PO

  • Clindamycin 25-40 mg/kg/day IV, in 3 divided doses, or 10-20 mg/kg/day PO, in 3 divided doses (may have cross-resistance and emergence resistance in erythromycin-resistant strains; induces resistance in MRSA)

  • TMP-SMZ 8-12 mg/kg (based on the TMP component) in 4 divided doses IV or 2 divided doses PO

In 2011, the IDSA published updated guidelines regarding management of MRSA in adults and children, and in 2012, the updated IDSA guidelines for the Diagnosis and Treatment of Diabetic Foot Infections were published. [67, 68] Readers are encouraged to check the IDSA guidelines Web site for the 2014 updated recommendations for the diagnosis and management of skin and soft-tissue infections. [2]

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