Which antibiotics are recommended to treat MRSA skin and soft-tissue infections (SSTIs)?

Updated: Jun 14, 2019
  • Author: Thomas E Herchline, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

The IDSA indicates that the following adult antibiotic regimens may be used to treat MRSA SSTIs [2] :

  • Vancomycin 30 mg/kg/day IV, in 2 divided doses (IV agent of choice for MRSA; penicillin-allergic patients)

  • Linezolid 600 mg IV q12h or 600 mg PO bid

  • Clindamycin 600 mg/kg IV q8h or 300-450 mg PO tid (may have cross-resistance and emergence resistance in erythromycin-resistant strains; induces resistance in MRSA)

  • Daptomycin 4 mg/kg IV q24h (may cause myopathy)

  • Doxycycline, minocycline 100 mg PO bid

  • TMP-SMZ 1-2 double-strength (DS) tablets PO bid


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