Which antibiotics are recommended to treat methicillin-sensitive Staphylococcus aureus (MSSA) skin and soft-tissue infections (SSTIs) in children?

Updated: Jun 14, 2019
  • Author: Thomas E Herchline, MD; Chief Editor: Michael Stuart Bronze, MD  more...
  • Print
Answer

The IDSA indicates that the following pediatric (except neonates) antibiotic regimens may be used to treat MSSA SSTI [2] :

  • Nafcillin or oxacillin 100-150 mg/kg/day IV, in 4 divided doses (IV agent of choice; inactive against MRSA)

  • Cefazolin 50 mg/kg/day IV, in 3 divided doses (for penicillin-allergic patients but not those with immediate hypersensitivity reactions)

  • Clindamycin 25-40 mg/kg/day IV, in 3 divided doses, or 10-20 mg/kg/day PO, in 3 divided doses (may have cross-resistance and emergence resistance in erythromycin-resistant strains; induces resistance in MRSA)

  • Dicloxacillin (PO agent of choice for MSSA) or cephalexin (for penicillin-allergic patients but not those with immediate hypersensitivity reactions), 25 mg/kg/day PO in 4 divided doses

  • TMP-SMZ 8-12 mg/kg (based on the TMP component) in 4 divided doses IV or 2 divided doses PO

Doxycycline and minocycline are not recommended in children younger than 8 years.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!