When is a blood culture or bloodwork necessary in the workup of cellulitis?

Updated: Jun 14, 2019
  • Author: Thomas E Herchline, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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For serious infections, perform a blood culture, Gram stain, and culture of needle aspiration or punch biopsy specimens to pinpoint the etiology. [2] Blood cultures are only positive in 5-15% of patients with cellulitis. Aspiration of the leading edge of cellulitis margins rarely yields positive results but may be performed if clinicians are facing difficult situations.

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